Table 1 |
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Summary effects of different molecules involved in inflammation in the obstructive nephropathy |
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Agent |
Effect |
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NF-κB |
Inflammatory gene expression Macrophage infiltration Renal tubular cell apoptosis |
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Ang II |
NF-κB activation Oxidative stress TGF-β upregulation Macrophage infiltration |
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TNF-α |
Macrophage infiltration Renal tubular cell death |
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IL-1 |
ICAM expression Macrophage infiltration Fibroblast activation |
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MIF |
Leukocyte activation Fibroblast proliferation |
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E,P,L Selectins |
Monocytes/macrophage and T cell infiltration Tubular apoptosis |
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VCAM, ICAM |
Interstitial inflammation Leukocyte infiltration |
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β-integrins |
Macrophage infiltration |
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MCP-1, RANTES, MIP-1α |
Macrophage recruitment |
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CCR1, CCR2 |
Leukocyte recruitment Interstitial fibrosis |
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JAMS |
Leukocyte recruitment |
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|
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M-CSF |
Macrophage infiltration, activation and proliferation Tubular apoptosis |
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IP-10 |
Leukocyte recruitment |
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TGF-β |
Monocyte/macrophage infiltration Fibroblast proliferation Tubular apoptosis |
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HGF |
Suppress macrophage infiltration Inhibit chemokine expression |
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OPN |
Macrophage infiltration Interstitial fibrosis Repress tubular cell apoptosis |
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iNOS |
Resistance to cell death Limit macrophage infiltration |
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Grande et al. Journal of Inflammation 2010 7:19 doi:10.1186/1476-9255-7-19 |
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