Simvastatin reduces the expression of caspase-3 in kidney evaluated at 14th day after SCI in rats. Caspase-3 expression in kidney of sham (A) vehicle (B) and simvastatin groups (C) was determined at 14th day following SCI. Kidney of sham group shows no positive staining of caspase-3. Increased expression of caspase-3 was seen in vehicle group (B, green fluorescence). Simvastatin treatment significantly reduced the expression of caspase-3 (C, green fluorescence). Photomicrographs are representative of n = 3 in each group. Magnification × 400.
Shunmugavel et al. Journal of Inflammation 2010 7:17 doi:10.1186/1476-9255-7-17