Simvastatin improves histomorphology of kidney evaluated at 14th day after SCI in rats. Histomorphology of kidney of sham (a) vehicle (b, c) and simvastatin (d, e) groups was determined by H & E staining. Histology of glomerular complex (arrow) and renal tubules in sham kidney was normal. Bladder hypertrophy results in renal tubular degeneration and glomerular dysfunction (b) and formation of crystals (arrow heads) and degeneration of glomerular wall (arrow) in spinal bladder kidneys (c). Simvastatin treatment significantly reduced the damage observed with renal tubules and glomerular complex (d & e arrows). Photomicrographs are representative of n = 3 in each group. Magnification (a × 400 and b-e × 600).
Shunmugavel et al. Journal of Inflammation 2010 7:17 doi:10.1186/1476-9255-7-17