Simvastatin improves histomorphology of spinal bladder evaluated at 14th day after SCI in rats. Histomorphology of spinal bladder of sham (a-c), vehicle (d-f) and simvastatin group (g-i) was determined by H & E staining. The transitional epithelium was 3 cell layers thick in sham and covered with membrane plaque (a; arrow). Hyperplasia and degeneration of epithelial layer and degeneration of lamina propria were observed in spinal bladder (d). Muscle layers were thick with little matrix in sham control (b) but degenerated with large matrix deposition in spinal bladder (e; arrow). Tunica adventia enclosed large space filled with matrix in spinal bladder (f). Simvastatin treatment significantly decreased the transitional epithelial hyperplasia (g) muscular hypertrophy (h) and matrix in tunica adventia (i; arrow). Photomicrographs are representative of n = 3 in each group. Magnification × 400.
Shunmugavel et al. Journal of Inflammation 2010 7:17 doi:10.1186/1476-9255-7-17