Simvastatin reduces the voided urine volume after SCI in rats. On day 1 post SCI, urine volume was 3.57 ± 0.21 ml in 12 hours. In vehicle group, the volume of urine retained in the bladder gradually decreased to 1.2 ± 0.13 ml on day 14. Simvastatin treated animals retained significantly lesser volume in the bladder from day 8 to 14. Sham animals retained less than 0.07 ml urine on all the days of experiment. Data are expressed as mean ± SD, n = 7.
Shunmugavel et al. Journal of Inflammation 2010 7:17 doi:10.1186/1476-9255-7-17