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Roles of selected transcription factors in vascular inflammation and aging |
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| Transcription Factors |
Pro-/Anti-inflammatory |
Selected Target Genes |
Alterations with Aging |
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| NF-κB |
Pro-inflammatory |
MCP-1, ICAM-1, NOS2 |
Increased |
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| HIF-1α |
Anti-inflammatory |
VEGF, SDF-1 |
Decreased |
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| Ets-1 |
Pro-inflammation |
MCP-1, VCAM-1, PDGF, p16INK4a |
Increased |
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| ERG |
Anti-inflammatory |
VWF, VE-Cad, Ang2, IL-8 |
Unknown |
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| PPAR-α, -γ |
Pro-inflammatory |
NF-|B, pro-inflammatory cytokines, NOS2, VCAM-1 |
Decreased |
Zhan et al. Journal of Inflammation 2009 6:16 doi:10.1186/1476-9255-6-16 |
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