Figure 2.

Suppression of COX 1 and COX 2 enzyme activity by plasma of rabbits 2 h after oral administration of PFE. Enzyme activity of COX 2 but not of COX 1 was inhibited significantly (P < 0.05) compared to control by plasma samples obtained 2 h after the oral ingestion of PFE (PFE-treated plasma). Suppression of COX 1 and COX 2 enzyme activity by control plasma samples did not reach statistical significance compared to purified enzymes provided in the kit (P > 0.05). Acetylsalicylic acid was used as positive control for inhibition of COX 1 and COX 2 enzyme activity and showed 100% inhibition at the concentrations used. Data shown is Mean ± SE derived from 4 experimental and 2 control plasma samples, each run in duplicate and differ without a common letter (P < 0.05)