Effect of LMP-420 in chronic DSS colitis. Chronic colitis was generated in wild type C57BL/6 mice by 3 cycles of 5 days of 3% DSS in drinking water, followed by 16 days of plain water. LMP-420 therapy was given parenterally (i.p.) or orally in food to groups of 5 mice, beginning after completion of the 3d administration of DSS and continuing throughout the final 16 day recovery period. All mice had severe colitis at the termination of the study. Histologic scores were calculated as described. No significant differences in histologic scores were observed in mice treated with LMP-420 doses of 0 – 45 mg/kg given i.p. (panel A) or 0 – 145 mg/kg given orally (panel B).
Hale and Cianciolo Journal of Inflammation 2008 5:4 doi:10.1186/1476-9255-5-4