Table 2

Inhibitory effect of SB-203580 on hyperalgesia in the Hargraeves model

COMPOUND

PAW WITHDRAWAL TIME PRE-DRUG TREATMENT (Seconds)

PAW WITHDRAWAL TIME POST-DRUG TREATMENT (Seconds)

Vehicle

10.7 ± 0.6

8.0 ± 0.8

Indomethacin (10 mg/kg)

11.1 ± 0.6

14.5 ± 0.6*

SB-203580 (30 mg/kg)

10.8 ± 0.9

12.2 ± 1.2*

SB-203580 (10 mg/kg)

11.1 ± 0.6

11.8 ± 1.4*

SB-203580 (3 mg/kg)

12.0 ± 0.7

10.9 ± 1.2*

The data are presented as the time for paw withdrawal from the heat source in seconds and are the mean ± S.E.M. from 10 rats per treatment group. The asterisk denotes a statistically significant difference (p < 0.05) between the vehicle and drug treatment groups.

Brown et al. Journal of Inflammation 2008 5:22   doi:10.1186/1476-9255-5-22