Figure 6.

Effect of JAK2 inhibitor on LPS-stimulated NO production in RAW 264.7 cells. Concentration dependent effect of the JAK2 inhibitor AG-490 (0–10 μM) on LPS (1 μg/ml)-stimulated NO production measured at 24 hr. Cells were stimulated and the culture medium harvested and assayed for nitrite content by Greiss assay. The data show that AG-490 was able to inhibit LPS-stimulated NO production. Results for the effects of the inhibitor are expressed mean ± SEM, **p < 0.01 vs no inhibitor, n = 6.