Table 5
|
TNF-α expression in bone |
||||||
| Score |
Cells Expressing TNF-α |
Intensity of TNF-α Expression |
Overall Score* (Cells Expressing × Intensity of Expression) |
|||
| % |
 |
% |
|
|||
|
|
||||||
| 0 IF Placebo |
1 |
0 |
2.0 ± 0.3 |
0 |
2.0 ± 0.0 |
5.0 ± 0.6b |
| 2 |
50 |
100 |
||||
| 3 |
50 |
0 |
||||
| 4 |
0 |
0 |
||||
| 126 IF Placebo |
1 |
33.3 |
1.7 ± 0.3 |
100 |
1.0 ± 0.0 |
1.7 ± 0.3c |
| 2 |
66.6 |
0 |
||||
| 3 |
0 |
0 |
||||
| 4 |
0 |
0 |
||||
| 504 IF Placebo |
1 |
33.3 |
1.7 ± 0.3 |
100 |
1.0 ± 0.0 |
1.7 ± 0.3c |
| 2 |
66.6 |
0 |
||||
| 3 |
0 |
0 |
||||
| 4 |
0 |
0 |
||||
| 0 IF LPS |
1 |
0 |
4.0 ± 0.0 |
0 |
4.0 ± 0.0 |
16.0 ± 0.0a |
| 2 |
0 |
0 |
||||
| 3 |
0 |
0 |
||||
| 4 |
100 |
100 |
||||
| 126 IF LPS |
1 |
33.3 |
1.3 ± 0.3 |
33.3 |
1.7 ± 0.3 |
2.0 ± 0.0c |
| 2 |
66.6 |
66.6 |
||||
| 3 |
0 |
0 |
||||
| 4 |
0 |
0 |
||||
| 504 IF LPS |
1 |
100 |
1.0 ± 0.0 |
33.3 |
1.7 ± 0.3 |
1.7 ± 0.3c |
| 2 |
0 |
66.6 |
||||
| 3 |
0 |
0 |
||||
| 4 |
0 |
0 |
||||
|
Mice were fed soy isoflavones (IF; 0, 126 or 504 mg aglycone equivalents of IF/kg diet) for 14-days prior to and during a 30-day exposure to LPS (1.33 μg/d). TNF-α expression was determined immunhistochemically. Chi-square analysis was performed on the % of cells expressing TNF-α and the intensity of expression. The overall score was calculated. Results for the overall score are expressed as means ± standard error. Values for a given parameter that share the same superscript letter are not statistically different (P > 0.05) from each other. P-value for LPS*Diet on overall scores is < 0.0001. | ||||||
Droke et al. Journal of Inflammation 2007 4:17 doi:10.1186/1476-9255-4-17 |
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