Table 2

Alterations in microarchitectural properties of trabecular bone of the femur distal metaphysis.
Treatment
 BV/TV (%)A
 TbN (1/mm3)B
 TbSp (mm)C
 TbTh (mm)D
 Conn Den (1/mm3)E
 SMIF
 Linear Attenuation
0 IF Placebo
 8.80 ± 0.01a
 3.89 ± 0.15a, c
 0.27 ± 0.01a
 0.051 ± 0.001
 58.97 ± 8.14a
 2.63 ± 0.10
 1.01 ± 0.02
0 IF LPS
 6.34 ± 0.01b
 3.25 ± 0.15b
 0.32 ± 0.01b, d
 0.052 ± 0.001
 40.56 ± 8.80a, b
 2.83 ± 0.15
 0.90 ± 0.06
126 IF Placebo
 8.80 ± 0.01a
 3.92 ± 0.10a
 0.26 ± 0.01a
 0.050 ± 0.002
 47.33 ± 6.72a, b
 2.91 ± 0.16
 1.01 ± 0.02
126 IF LPS
 6.52 ± 0.01b
 3.41 ± 0.13b, e
 0.30 ± 0.01b, c, d
 0.050 ± 0.001
 33.56 ± 3.80b
 3.02 ± 0.05
 0.95 ± 0.02
504 IF Placebo
 7.14 ± 0.01a, b
 3.50 ± 0.17b, c, d
 0.29 ± 0.02a, d
 0.050 ± 0.001
 34.12 ± 4.99b
 2.96 ± 0.14
 0.96 ± 0.03
504 IF LPS
 8.40 ± 0.01a, b
 3.71 ± 0.14a, d, e
 0.28 ± 0.01a, c
 0.053 ± 0.002
 52.12 ± 8.87a, b
 2.93 ± 0.15
 1.00 ± 0.02
P value






LPS
 0.0731
 0.0085
 0.119
 0.2834
 0.4317
 0.3779
 0.1018
IF
 0.9681
 0.7839
 0.5918
 0.2478
 0.4208
 0.1493
 0.6326
LPS*IF
 0.0397
 0.0099
 0.0124
 0.6706
 0.0341
 0.6773
 0.0613

Mice were fed soy isoflavones (IF; 0, 126 or 504 mg aglycone equivalents of IF/kg diet) for 14-days prior to and during a 30-day exposure to LPS (1.33 μg/d). Results are expressed as means ± standard error. (A) trabecular bone volume (BV/TV), (B) trabecular number (TbN), (C) trabecular separation (TbSp), and (D) trabecular thickness (TbTh), (E) Connective Density (Conn Den), (F) Structure Model Index (SMI). Values for a given parameter that share the same superscript letter are not statistically different (P > 0.05) from each other.

Droke et al. Journal of Inflammation 2007 4:17   doi:10.1186/1476-9255-4-17