|
Total and differential cell counts of BAL fluid from MMP-12 -/- and WT mice 14 days after intranasal administration of bleomycin (BLM) or saline vehicle (Control). Results are presented as the mean (.103 cells) ± SEM. n: number of mice. a: P < 0.05, b: P < 0.01, c: P < 0.001 compared with control mice exposed to saline solution only. |
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| Treatment |
Strain |
N |
Total cells |
Macrophages |
Neutrophils |
Eosinophils |
Lymphoytes |
|
|
|||||||
| Control |
WT |
5 |
579 ± 92 |
561 ± 79 |
13 ± 10 |
0 ± 0 |
6 ± 6 |
| MMP-12 -/- |
5 |
547 ± 92 |
540 ± 94 |
2 ± 2 |
0 ± 0 |
4 ± 4 |
|
| BLM |
WT |
8 |
2204 ± 284c |
1783 ± 210c |
285 ± 78b |
55 ± 19b |
81 ± 33b |
| MMP-12 -/- |
8 |
1352 ± 355a |
1152 ± 255a |
104 ± 62b |
19 ± 17 |
76 ± 55 |
|
Manoury et al. Journal of Inflammation 2006 3:2 doi:10.1186/1476-9255-3-2 |
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