Figure 4.

A. Representative gelatin zymogram of BAL supernatant fluids 14 days after intranasal administration of bleomycin (BLM) or saline vehicle (Control) to WT and MMP-12 -/- mice. M: molecular weight marker. B : Quantification by densitometry of 64 kDa MMP-2 gelatinase activity on zymograms of BAL fluid, performed 14 days after intranasal administration of bleomycin (BLM) or vehicle saline (Control), in wild type mice (WT) (blank bars) and MMP-12 -/- mice (solid bars). Results are represented as the mean ± SEM. * : P < 0.05 compared to corresponding control. N = 4–8.